What is Kiomedine®?

KioMedine^vsone  is a sterile liquid implant intended for synovial fluid supplementation and classed as a medical device.

KioMedine^vsone is used to relieve symptoms related to osteoarthritis of the knee, such as pain, in adults aged 18 years and above.

KioMedine^vsone works by providing lubrication, reducing friction in the joint and protecting synovial polymer from being broken down.

KioMedine^vsone is injected directly into the knee joint by a doctor/healthcare professional experienced in intra-articular injections.

KioMedine^vsone is made of 60 mg of a chitosan derivative, 105 mg of sorbitol, and phosphate-buffered water for injection. The 3 mL volume of KioMedine one is suitable for an injection into one knee.

Warnings

You must not receive KioMedine one if:

• You have had an allergic reaction to any of the ingredients. KioMedine one is derived from polysaccharides of edible mushrooms and should not be injected in patients with related allergies.
• You have an infection or a skin disease at or around the injection site (area of the knee).
• You suffer from severe inflammation, synovitis (inflammation of the knee joint) or inflammatory arthritis of the knee joint.
• You have a history of autoimmune diseases or gout (or other crystal diseases).
• You suffer from lymphatic or venous stasis or serious blood disorders.
• You are pregnant or breastfeeding.
• You are under 18 years of age.