What are the possible side effects of a Kiomedine® injection?

Most common side effects:

• joint pain, stiffness, and swelling,
• pain or reactions at the injections site,
• reduced mobility and buildup of fluid in the knee (effusion).

These effects are temporary but can last from 1 day to 1 week, and may affect your daily activities. However, they can be managed with rest, cold application, pressure bandage, oral painkillers (such as paracetamol), and/or non-steroidal anti-inflammatory drugs (such as ibuprofen).

Less common side effects:

• synovitis (inflammation of the synovial membrane of a joint), inflammation,
• rash, itching, mild allergic reaction,
• low-grade fever,
• generally feeling unwell, or
• inability to fully move a joint (joint lock), difficulty to walk.

Other possible side effects:

• Local reactions: infection, inflammation of the small sacs of fluid that cushion the knee joint (bursitis), joint warmth, cracking of the knee, joint diseases (arthropathy), worsening of the osteoarthritis, leakage of fluid (discharge).
• Distant reactions: muscle cramps or spasms, flushing, chills, nausea, headache, low or high blood pressure, back pain, pain or swelling in lower legs or hands.

If the side effects persist for over 1 week or worsen significantly after the injection, you should contact your doctor. You can report any serious incident related to the injection to vigilance-rheumatology@kiomedpharma.com or to your local health authorities.